Increasing possibilities of nanosuspension by kumar bishwajit sutradhar, sabera khatun and irin parven luna no static citation data no static citation data cite. Possibilities of increasing coal charge density by adding fuel oil. Currently more than 40% of new chemical entities are reported to be lipophilic compounds and onethird of drugs recognized by united states pharmacopeia are poorly soluble chen et al. Review article increasing possibilities of nanosuspension kumar bishwajit sutradhar, sabera khatun, and irin parven luna department of pharmacy, stamford university bangladesh, 51 siddeswari road, dhaka 1217, bangladesh correspondence should be addressed to kumar bishwajit sutradhar. Nanosuspensions are fine dispersion of uniformsized solid particles in an aqueous vehicle. Nanosuspension have emerged as a promising strategy for the efficient delivery of hydrophobic drugs. Nanosuspension for enhancement of oral bioavailability of felodipine. Nanosuspension a novel approaches in drug delivery system chaudhari shilpa p, kamble. Preparation, characterization and stabilization of.
Patel pharmacy college, linch, mehsana, gujarat, india 2nootan pharmacy college, visnagar384315, gujarat, india. Formulation and comparative evaluation of hpmc and water. Formulations were designed based on full factorial design. Nanosuspension a pharmaceutical nanosuspension is defined as very finely dispersed solid drug particles in an aqueous or organic vehicle for either oral and topical use or parenteral and pulmonary administration. The homogenized nanosuspension was freeze dried by using virtis freeze dryer for increasing the shelf life of suspension and to study the dissolution behavior. Potential benefits of nanosuspension technology for. Solidification of nanosuspension via spray granulation.
Increasing possibilities of nanosuspension hindawi. Formulation and optimization of nanosuspensions for. Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma pc3 cell line. The aim of the present study was to enhance the pharmaceutical potential and oral bioavailability of piperine, which is the bioactive constituent of piper nigrum, using the nanosuspension approach. Consequently, it can increase saturation solubility determined by. Furthermore, an increase in particle size and pdi by increasing the concentration of the stabilizer may result from ostwald ripening.
An increasing amount of amorphous drug fraction could induce higher saturation solubility. To avoid this problem, nanotechnology for drug delivery has gained much interest as a way to improve the solubility problems. Arshad ahmed khan department of pharmaceutics, raghavendra institute of pharmaceutical education and research, anantapuramu515721, andhra pradesh, india. Dissolution enhancement of nifedipine by preparing drug.
A nanosuspension not only solves the problem of poor solubility and bioavailability but also alters the pharmacokinetics of drug and that improves drug safety and e cacy. Schematic diagram of preparation methods of nanosuspension. Pdf increasing possibilities of nanosuspension kumar. Nanosuspension free download as powerpoint presentation. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and h96 approach and to evaluate the effectiveness of h96 approach. Nanosuspension has been reported to enhance absorption and bioavailability.
In another study, the particle size of resveratrol nanosuspension was increased by increasing the amount of the drug and concentration of the stabilizer. Summary of nanosuspension formation technologies and compounds produced in nanosuspension. The reduction of drug particles into the submicron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. Employment analysis of the turkish banking sector and possibilities for increasing the employment capacity. Nowadays, nanosuspension is a growing approach for pharmaceutical product development due to several unique properties applicable in pharmaceutical field. Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of. Figure 3 increasing possibilities of nanosuspension. Thus, improving oral bioavailability of olm can increase clinical efficacy. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable contributing to deserted development effort.
Nanosuspension formulation approach is most suitable for the compounds with high log p value, high melting point and high dose. Preparation of nanosuspension is simple and applicable to. A nanosuspension is a submicron colloidal dispersion of drug particles. Increasing possibilities of nanosuspension mafiadoc.
Investigation of a nanosuspension stabilized by soluplus. Lutful amin 1 1 department of pharmacy, stamford university bangladesh, 51, siddeswari road, dhaka1217, bangladesh. Nanosuspension resolves the problem of poor bioavailability by solving the problem of. Agglomeration, nanosuspension, ostwald ripening, stability issues, stability of nanosuspension, steric stabilization. Pharmapharmaceutics iii sem amity institute of pharmacy 2. Solidification of nanosuspension via spray granulation yidan lan1, srikanth kakumanu2, carl beckett2, nigel langley1 1 basf corporation, pharma ingredients and services, 500 white plains road, ny 10591 2 covaris incorporated, 14 gill street, woburn, ma 01801 yidan. Nanosuspension for enhancement of oral bioavailability of. Formulation and optimization of nanosuspensions for enhancing simvastatin dissolution using central composite design vikram m. In case of drugs that are insoluble in both water and in organic media instead of using lipidic systems, nanosuspensions are used as a formulation approach. Increasing the amorphous fraction in the particles, leading to a potential change in. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin a.
A high pressure homogenization technique was used to produce nanosuspensions. Increased zeta potential values indicate that the formulation has good. Zeta potential of the optimized formulation was measured using the same instrument. Nanosuspension consists of the pure poorly watersoluble drug without any matrix material suspended in dispersion. During the process of drug exploration and investigation, more and more new drug candidates have been found to be insoluble or poorly soluble in aqueous medium or organic solvent grau et. Nanosuspension has been found to possess great potential to rectify the several. Emerging role of nanosuspensions in drug delivery systems. Preparation and evaluation of vitamin a nanosuspension as. The interest in the preparation and application of nanometersized materials is increasing due to their tremendous potential as a drug delivery system with wide range of applications. Preparation and characterization of nanosuspension of.
The nanosuspensions were subjected to evaluations involving particle size, dissolution. Formulation as nanosuspension is an attractive and promising alternative to solve these problems. Introduction 3 nanosuspension can be defined as a biphasic system consisting of pure drug particles dispersed in a aqueous vehicle in which the diameter of the suspended particle is less than 1. Pdf increasing possibilities of nanosuspension researchgate. Nowadays, a very large proportion of new drug candidates emerging from drug discovery programmes are water insoluble and thus poorly bioavailable. Nanosuspension consist of the poorly water soluble compound without any matrix material suspended in dispersion. Increasing possibilities of nanosuspension kumar bishwajit sutradhar, sabera khatun, and irin parven luna depar tment of pharmac y, stamford university bangl adesh, 51 siddeswari road, dhaka 1. Nanosuspension a novel approaches in drug delivery system. The main possibilities for improving dissolution according to this analysis are to increase the surface area available for dissolution by decreasing the particle size of the solid dispersion. Nanosuspensions are also use in various dosage forms, including specialized drug delivery system such as mucoadhesive hydrogel. However, the most attractive option for increasing the release rate is improvement of the solubility through formulation. Nanosuspensions are colloidal dispersions of nanosized drug particles stabilized by surfactants.
In recent years nanoemulsion has become a promising tool to improve bioavailability of several drugs along with nanosuspension and other various solubility enhancement techniques 61. To avoid this problem, nanotechnology for drug delivery has gained much interest as a way to improve. Sparfloxacin ons were prepared by optimizing the concentration of hpmc e5 and water soluble chitosan by using solvent diffusion method followed by. Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. Nanosuspension pharmaceutical formulation solubility. Kumar bishwajit sutradhar, sabera khatun, and irin parven luna. Pdf increasing possibilities of nanosuspension sabera. Review article increasing possibilities of nanosuspension. Review article nanosuspension drug delivery 1jain amit k. Methyl cellulose as promising stabilizer nehal daebis 1, ossama y abdallah2, magda elmassik, and hamdy abdelkader3 1department of pharmaceutics, faculty of pharmacy and drug manufacturing, pharos university, alexandria, egypt. Nanosuspension international journal of pharmaceutical sciences. Formulation and characterization of itraconazole oral nanosuspension. The oral bioavailability of poorly water soluble drug can be improved using nanosuspension.
The objective of the study was to assess the effect of surfactants and polymers on particle size and drug release. Oral drug delivery of nanosuspension with receptor mediated endocytosis has the. Formulation and characterization of itraconazole oral. Development and characterization of nanosuspensions of. Dissolution enhancement of nifedipine by preparing drug nanosuspensions using media milling technique 5. Fifteen formulations were prepared by the use of different combinations of. Increasing possibilities of nanosuspension open access. The main challenge in nanosuspension technology is prevention of particle agglomeration or aggregation and crystal growth. Various techniques for preparation of nanosuspension a. Chabot, demonstrated that nanoemulsion formulation of fisetin improves its bioavailability and antitumour activity in mice 49. Kulkarni abstract nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages.
Csa nanosuspension was prepared by high pressure homogenization technology. Nanosuspension has shown to have greater drug loading compared to other oral dosage form, and thus, lower dose is required to achieve intended therapeutic effect and patient compliance can be improved with the use of this drug delivery system yadav and singh, 2012. In nanosuspension technology, the drug is maintained in the required crystalline state with reduced particle size, leading to an increased dissolution rate and therefore improved bioavailability. Nanoprecipitation, which is a simple and reproducible process, was used for. Schematic representation of the media milling process. Nanosuspension enhance bioavailability 15 drug with poor solubility, poor permeability or poor solubility in gastrointestinal tract will leads to poor oral bioavailability. Nanosuspension technology can be used to improve the stability as well as bioavailability of poorly soluble drug.
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